Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson’s disease
Identifieur interne : 000E42 ( Main/Exploration ); précédent : 000E41; suivant : 000E43Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson’s disease
Auteurs : M K York [États-Unis] ; M. Dulay [États-Unis] ; A. Macias [États-Unis] ; H S Levin [États-Unis] ; R. Grossman [États-Unis] ; R. Simpson [États-Unis] ; Joseph Jankovic [États-Unis]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2008-07.
Abstract
Background: We investigated the cognitive and psychiatric outcome 6 months after bilateral subthalamic nucleus deep brain stimulation (DBS) for the treatment of Parkinson’s disease (PD) using a disease control group. Methods: 23 patients who underwent DBS were compared with 28 medically treated patients with PD at baseline and at 6 months for neuropsychological measures. In addition to the group outcomes, we report reliable change indices (RCI) and a dementia caseness analysis. Results: Patients who underwent DBS demonstrated a significant decline in verbal memory compared with the control group (p<0.003), and trends for decline on oral information processing, including verbal fluency, timed transcription and word naming. Patients who underwent DBS demonstrated declines in attention, set shifting and semantic fluency but these changes were similar to the rate of decline in the PD group. RCI indicated that patients who underwent DBS demonstrated clinically significant declines in verbal fluency (p<0.01) and inhibition of a dominant response (p<0.003), with trends for declines in set shifting (p<0.02) and verbal long term recall (p<0.08), indicative of frontostriatal dysfunction. Patients who underwent DBS did not demonstrate significant changes in depression, anxiety or psychological distress scores. The caseness analysis revealed that one of the patients who underwent DBS (4%) converted to dementia over 6 months compared with none of the PD controls. Conclusions: Our findings demonstrated that patients who underwent DBS experienced declines in verbal recall and trends for declines in oral information processing 6 months following surgery, even when good motor outcome was achieved. Potential candidates should be counselled about the risk of mild frontostriatal cognitive declines following DBS to weigh the risks and benefits of surgery.
Url:
DOI: 10.1136/jnnp.2007.118786
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson’s disease</title><author><name sortKey="York, M K" sort="York, M K" uniqKey="York M" first="M K" last="York">M K York</name></author><author><name sortKey="Dulay, M" sort="Dulay, M" uniqKey="Dulay M" first="M" last="Dulay">M. Dulay</name></author><author><name sortKey="Macias, A" sort="Macias, A" uniqKey="Macias A" first="A" last="Macias">A. Macias</name></author><author><name sortKey="Levin, H S" sort="Levin, H S" uniqKey="Levin H" first="H S" last="Levin">H S Levin</name></author><author><name sortKey="Grossman, R" sort="Grossman, R" uniqKey="Grossman R" first="R" last="Grossman">R. Grossman</name></author><author><name sortKey="Simpson, R" sort="Simpson, R" uniqKey="Simpson R" first="R" last="Simpson">R. Simpson</name></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:729C25B07A55F6210579AD319210C9EB9E3FB761</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1136/jnnp.2007.118786</idno><idno type="url">https://api.istex.fr/document/729C25B07A55F6210579AD319210C9EB9E3FB761/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002830</idno><idno type="wicri:Area/Main/Curation">002484</idno><idno type="wicri:Area/Main/Exploration">000E42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson’s disease</title><author><name sortKey="York, M K" sort="York, M K" uniqKey="York M" first="M K" last="York">M K York</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Dulay, M" sort="Dulay, M" uniqKey="Dulay M" first="M" last="Dulay">M. Dulay</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor College of Medicine, Department of Neurosurgery, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Macias, A" sort="Macias, A" uniqKey="Macias A" first="A" last="Macias">A. Macias</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Levin, H S" sort="Levin, H S" uniqKey="Levin H" first="H S" last="Levin">H S Levin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor College of Medicine, Department of Physical Medicine and Rehabilitation, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Grossman, R" sort="Grossman, R" uniqKey="Grossman R" first="R" last="Grossman">R. Grossman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Methodist Hospital Neurological Institute, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Simpson, R" sort="Simpson, R" uniqKey="Simpson R" first="R" last="Simpson">R. Simpson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Methodist Hospital Neurological Institute, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor College of Medicine, Department of Neurology-The Parkinson’s Disease and Movement Disorders Clinic, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2008-07">2008-07</date><biblScope unit="volume">79</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="789">789</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">729C25B07A55F6210579AD319210C9EB9E3FB761</idno><idno type="DOI">10.1136/jnnp.2007.118786</idno><idno type="href">jnnp-79-789.pdf</idno><idno type="ArticleID">jn118786</idno><idno type="PMID">17965146</idno><idno type="local">jnnp;79/7/789</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background: We investigated the cognitive and psychiatric outcome 6 months after bilateral subthalamic nucleus deep brain stimulation (DBS) for the treatment of Parkinson’s disease (PD) using a disease control group. Methods: 23 patients who underwent DBS were compared with 28 medically treated patients with PD at baseline and at 6 months for neuropsychological measures. In addition to the group outcomes, we report reliable change indices (RCI) and a dementia caseness analysis. Results: Patients who underwent DBS demonstrated a significant decline in verbal memory compared with the control group (p<0.003), and trends for decline on oral information processing, including verbal fluency, timed transcription and word naming. Patients who underwent DBS demonstrated declines in attention, set shifting and semantic fluency but these changes were similar to the rate of decline in the PD group. RCI indicated that patients who underwent DBS demonstrated clinically significant declines in verbal fluency (p<0.01) and inhibition of a dominant response (p<0.003), with trends for declines in set shifting (p<0.02) and verbal long term recall (p<0.08), indicative of frontostriatal dysfunction. Patients who underwent DBS did not demonstrate significant changes in depression, anxiety or psychological distress scores. The caseness analysis revealed that one of the patients who underwent DBS (4%) converted to dementia over 6 months compared with none of the PD controls. Conclusions: Our findings demonstrated that patients who underwent DBS experienced declines in verbal recall and trends for declines in oral information processing 6 months following surgery, even when good motor outcome was achieved. Potential candidates should be counselled about the risk of mild frontostriatal cognitive declines following DBS to weigh the risks and benefits of surgery.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="York, M K" sort="York, M K" uniqKey="York M" first="M K" last="York">M K York</name></region><name sortKey="Dulay, M" sort="Dulay, M" uniqKey="Dulay M" first="M" last="Dulay">M. Dulay</name><name sortKey="Grossman, R" sort="Grossman, R" uniqKey="Grossman R" first="R" last="Grossman">R. Grossman</name><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name><name sortKey="Levin, H S" sort="Levin, H S" uniqKey="Levin H" first="H S" last="Levin">H S Levin</name><name sortKey="Macias, A" sort="Macias, A" uniqKey="Macias A" first="A" last="Macias">A. Macias</name><name sortKey="Simpson, R" sort="Simpson, R" uniqKey="Simpson R" first="R" last="Simpson">R. Simpson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E42 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E42 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:729C25B07A55F6210579AD319210C9EB9E3FB761
|texte= Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson’s disease
}}
| This area was generated with Dilib version V0.6.23. |  |